Ei ole epäilystäkän siitä etteikö borreliabakteeri aiheuttaisi neurologisia sairauksia. Asiasta on esitetty tutkimuksia jo vuosikymmenten ajan.
(Sivulla olevista linkeistä löytyy aihetta käsitteleviä tutkimuksia.)
Borrelioosissa esiintyy samanlaisia aivomuutoksia joita tavataan esim. MS-taudissa (oireistossa). Vauriot saattavat korjautua antibioottihoidolla mutta eivät välttämättä. Joillekin jää vaurioita loppuelämän ajaksi. Voiko borreliabakteeri aiheuttaa hallitsemattomia vihanpurkauksia? Monien lääkäreiden/psykiatrien mukaan kyllä voi. Erittäin vihamielinen, murhanhimoinen käyttäytyminen on kuitenkin erittäin harvinaista. Neuropsyykkiset oireet ovat moninaisia, esim. itsemurhia esiintyy sairastuneiden kohdalla.
Neuroborrelioosin tavallisimmat oireet ovat neuropatia, esim. puutumista, pistelyä, hermokipua, muistihäiriöitä, voimakasta uupumusta jne. Psyykkisinä oireina esiintyy esim. masennus, ahdistus, paniikkikohtaus, harhaisuus, hallusinaatio, voimakas vihanpurkaus jne. Voimakasoireista neurologista borrelioosia sairastava saattaa eksyä maantiellä tai hänellä on vaikeuksia lukea ja ymmärtää lukemaansa tekstiä.
Mikäli lääkärisi epäilee sinun sairastavan neuroborrelioosia, oireinasi saattaa esiintyä esim. päänsärky, kasvohermohalvaus, aivokalvontulehdus, raajojen heikotus, puutuminen, ristiselkäkipu (iskias), kognitiiviset häiriöt kuten ongelmia ajattelussa, järkeilyssä, muistissa jne."
Viestin lopussa esitetään tutkimuksia joiden mukaan borreliabakteeri kykenee aiheuttamaan erilaisia psyykkisiä oireita. Artikkelissa ihmetellään CDC:n ja IDSA:n, Gary Wormserin, kannanottoja joissa kyseenalaistetaan borreliabakteerin aiheuttamat neuropsykiatriset oireet. Kannanotto liittynee IDSA:n systemaattisiin pyrkimyksiin kieltää borrelioosin kroonistuminen.
Aiheesta kerrottiin myös TV-uutisissa, News Channel 5. Videolla lääkäri Schaffner väittää ettei borreliabakteeri aiheuta psykooseja eikä tauti edes ole kovin yleinen. Ohjelmassa esiintynyt borrelioosia sairastava nainen kehottaa Schaffneria päivittämään tietonsa borrelioosista. Hänen mukaansa tauti on vaarallinen ja sitä sairastavia on runsaasti.
Illinois Shooting Renews Lyme Disease Debate
Posted: March 11, 2009 06:38 AM
NASHVILLE, Tenn. - A crowded sanctuary, a loaded gun, and a man with enough ammunition to kill 30 people. Sunday's murder of a church pastor in Illinois has investigators looking into the medical history of the suspected shooter.
The incident has renewed the debate on an illness that has cropped-up in Middle Tennessee.
The question remains, was the illness a factor in the murder of Pastor Fred Winters? Could Lyme disease push a person to kill?
Vanderbilt Infectious Disease Specialist Dr. Bill Schaffner never treated church shooting suspect Terry Joe Sedlacek, but he is treating the growing suspicion that a tick-borne illness might have made Sedlacek homicidal.
"There is no evidence in the medical literature that Lyme disease, in whatever form - and that's also debatable - could pre-dispose one to violent, psychotic and evil behavior," sayd Schaffner.
Some patients who live with the disease would refute the doctor's claims.
"I don't think anybody can say that," says Mary Ann Pickard.
Pickard suffers from Lyme disease. She loves the outdoors, but loathes the lifelong illness she says nature inflicted on her.
Pickard says the disease has been debilitating, but on her worst day, she has never felt violent.
"I would suggest that he get up to date on current information, because there are now more cases of Lyme Disease than AIDS in the United States," says Pickard.
Schaffner insists Tennessee physicians base their findings, not on a feeling, but on fact. Cold, hard numbers that show the Volunteer State has a very low occurrence of the illness.
The latest numbers from the state health department reflect just one case so far this year.
One case is likely not cause for alarm, but Lyme Disease patients have long maintained the reporting method is flawed, saying that Lyme is under-diagnosed.
Pastor killing: Another act of violence attributed to Lyme disease
By Pamela Weintraub on March 9, 2009 - 6:30am in Emerging Diseases
http://blogs.psychologytoday.com/blog/e ... me-disease
On the heels of the rage-filled chimp story comes a human version: This weekend a man opened fire on a pastor in a church in Maryville, Illinois, murdering him with a rain of gunfire. Here, too, the explanation for the attack has been given as psychiatric illness caused by Lyme disease. Infected by a tick on the family farm in the early 1990's, the young man was, his family said, left with lesions on his brain.
There's no question that Lyme disease is a neurological illness. It has been associated with neurological disease for decades in rigorous peer review in the top medical journals in the world
For a quick review of neurological Lyme disease and its psychiatric links, check out the blog posts:
part one, part two, part three, and a psychiatrist gets Lyme disease.
Lyme disease may certainly form brain lesions much like those seen in multiple scleroisis. These lesions are often reversible with antibiotic therapy, but are sometimes irreversible and seen in patient brain scans for life.
Can Lyme disease provoke rage? Many psychiatrists and doctors working in the trenches with some of the sickest patients say the answer is yes, as do reports in the peer review. But murderous violent crime is not the typical M.O. for a patient with Lyme. Mental illness exists apart from Lyme disease and even adverse reactions to antidepressants and other antipsychotic drugs could provoke outsized rage. Once psychiatric symptoms emerge from Lyme disease, outcomes may include everything from suicide to severe adverse reactions to psychoactive drugs.
The most common symptoms of neurological Lyme disease include neuropathies that involve buzzing and tingling, nerve pain, memory loss, confusion, and fatigue. Psychiatric problems like depression, anxiety, OCD, and ADD can be triggered by Lyme or other tick-borne infections, according to studies. Panic attacks, hallucinations, delusions, and extreme rage have all been reported in Lyme patients but compared to memory loss and confusion, these presentations are rare. A patient with severe neurological Lyme disease is far more likely to get lost on the road or have trouble reading than shoot up a Church.
While Lyme disease is not known for triggering killing sprees, the Infectious Diseases Society of America (IDSA) appears to have taken a bizarre stance by apparently dismissing most presentations of neurological Lyme disease at all. "In some rare cases, people may have neurologic problems such as facial paralysis," the group concedes in a press release on the situation, listing this single symptom and no others. The group cites a 95% cure rate for Lyme disease, failing to mention that the statistic refers only to early disease; that number has been called into question by some academic heavyweights due to new findings on Lyme strains. But more disturbing, IDSA fails, in its release, to mention the late-diagnosed Lyme cases (and due to flawed tests, there are many of these) that give rise to the lion's share of neurological forms of the disease.
What is especially misleading is that the IDSA statement fails to take note of the true mainstream authority on neurological Lyme disease, the American Academy of Neurology. That group, whose practice guidelines hold sway in mainstream circles on this painful and sometimes-devastating condition, says this:
If you or a family member have been told by a doctor that you have nervous system Lyme disease, regardless of age, your symptoms may include headache, facial nerve palsy (Bell?s palsy), and meningitis (swelling and pain in the membrane surrounding the brain). Rarely the brain or spinal cord may become inflamed, causing weakness or changes to the nerve impulses in parts of the body, or other symptoms. Patients with nervous system Lyme disease may also have one or more of these symptoms: radicular (sciatica-like nerve) pain, weakness or numbness due to nerve damage, or changes in cognitive function (thinking, reasoning, remembering, imagining).
Shame on you IDSA! In a situation where balance is required, extremism, including exaggeration or diminishment of a real situation, only muddies the waters and leaves everyone confused.
On Monday, March 9, the Associated Press reported that that attacker, Terry J. Sedlacek, 27, of Troy, was charged with two counts each of first-degree murder and aggravated battery, for gunning down the pastor and then stabbing himself and two worshippers who tried to tackle him down.
Scientific evidence for ?Lyme Rage?
March 11th, 2009 | Category: Controversy, Patient Stories, Science
Posted by: Kris
In light of the tragic shooting in Illinois, we?d like weigh in on the issue of whether the shooter?s case of late-stage Lyme disease could have caused violent behavior. First, during our four years of research for the film, UNDER OUR SKIN, we interviewed a number of patients who had bouts of ?Lyme Rage? before appropriate treatment. While it doesn?t seem that common, it does seem possible. In addition, many of the physicians we interviewed, specifically the ones who treat a large number of Lyme patients, acknowledge that they have had patients with Lyme Rage. And finally, there are over 100 peer-reviewed medical journal articles linking tick-borne diseases to mental symptoms and quite a few that document Lyme-induced rages. For your convenience, I?ve cited some of these articles at the bottom of this post.
In this morning?s press, the IDSA and CDC came out with guns blazing, denying the possibility of Lyme Rage.
Dr. Gary Wormser, the lead author of the controversial Infectious Disease Society of Americe (IDSA) Lyme guidelines, said, on WebMD:
?I don?t know of any convincing evidence that Lyme disease can cause violence or psychosis.?
Paul Mead, a medical epidemiologist with the CDC, said in an article by Roger Schlueter of the News-Democrat:
?So the spirochete certainly can, in the lab, attach to nerve cells, and it certainly causes acute inflammation of nervous tissue,? Mead said. ?But whether that would cause psychiatric illness is, as far as I know, impossible to say.?
While I personally find their Lyme denialism baffling, I encourage those of you interested in the science to read the peer-reviewed journal articles listed below, and decide for yourself.
The News-Democrat also cites the Prague study, which says:
?In 2002, a study at the Prague Psychiatric Center involving 1,900 people found that people with psychiatric illness had about a 30 percent increased incidence of Lyme disease antibodies in their blood compared to other study participants.?
Isn?t it worth keeping our minds open to the emerging evidence that the Lyme bacteria ? a neurologically invasive spirochete just like syphilis ? could be the root cause of a myriad of psychiatric disorders that are currently considered incurable? How costly to our society and inhumane to medicate and lock up thousands of supposedly mentally ill people, when they may have a treatable bacterial infection.
Lyme-Induced Psychiatric Disorders
Peer-Reviewed Literature from Around the World
Lyme disease: a neuropsychiatric illness.
Fallon BA, Nields JA. Am J Psychiatry. 1994 Nov;151(11):1571-83.
?A broad range of psychiatric reactions have been associated with Lyme disease including paranoia, dementia, schizophrenia, bipolar disorder, panic attacks, major depression, anorexia nervosa, and obsessive-compulsive disorder.?
Late-stage neuropsychiatric Lyme borreliosis. Differential diagnosis and treatment.
Fallon BA, Schwartzberg M, Bransfield R, Zimmerman B, Scotti A, Weber CA, Liebowitz MR. Psychosomatics. 1995 May-Jun;36(3):295-300.
?Although dermatologic, articular, cardiac, ophthalmologic, and neurologic manifestations are well known, it is less well known that psychiatric disorders may also arise. Depression, panic attacks, schizophrenia-like psychotic state, bipolar disorder, and dementia have been attributed to Lyme borreliosis.?
Functional brain imaging and neuropsychological testing in Lyme disease.
Fallon BA, Das S, Plutchok JJ, Tager F, Liegner K, Van Heertum R.
Clin Infect Dis. 1997 Jul;25 Suppl 1:S57-63. Review.
?Patients with Lyme disease may experience short-term memory loss, severe depression, panic attacks, unrelenting anxiety, impulsivity, paranoia, obsessive compulsive disorder, personality changes marked by irritability and mood swings, and rarely, manic episodes or psychotic states.?
The underdiagnosis of neuropsychiatric Lyme disease in children and adults.
Fallon BA, Kochevar JM, Gaito A, Nields JA.
Psychiatr Clin North Am. 1998 Sep;21(3):693-703, viii.
?In addition to the disorders listed by Kohler and Omasitis, Lyme disease appears to be capable of causing syndromes that manifest as personality change, depersonalization, mania, hallucinations, (auditory, visual, and olfactory), paranoia, cataonia with stupor and mutism, somatization disorder, obsessive compulsive disorder, violent outbursts, panic attacks and disorientation.?
The neuropsychiatric manifestations of Lyme borreliosis.
Fallon BA, Nields JA, Burrascano JJ, Liegner K, DelBene D, Liebowitz MR.
Psychiatr Q. 1992 Spring;63(1):95-117. Review.
?Lyme disease is aptly called the ?new great imitator,? and it can imitate psychiatric disorders no less than medical ones. Psychiatrists working in endemic areas are well advised, then, to keep Lyme disease in mind as part of their differential diagnosis for a broad range of disorders including, for instance, panic attacks, somatization disorder, depression, and dementia.?
A 25-year-old woman with hallucinations, hypersexuality, nightmares, and a rash.
Stein SL, Solvason HB, Biggart E, Spiegel D.
Am J Psychiatry. 1996 Apr;153(4):545-51.
?The [Lyme] patient expressed a delusional belief that she was controlled by an attractive popular male former high school teacher who had put a curse on her family before her birth and was now sexually obsessed with her.?
Germany: Neurologische Klinik mit Poliklinik, Universität Freiburg.
Lyme borreliosis in neurology and psychiatry
Kohler J. Fortschr Med. 1990 Apr 10;108(10):191-3, 197.
?Involvements of the CNS are expressed not so much in focal deficits, as in diffuse psychopathological disorders? The clinical symptomatology may be dominated by severe psychiatric syndromes.?
Czechoslovakia: Prague Psychiatric Center
T. Hajek: email@example.com
Higher prevalence of antibodies to Borrelia burgdorferi in psychiatric patients than in healthy subjects.
Hájek T, Pasková B, Janovská D, Bahbouh R, Hájek P, Libiger J, Höschl C. Am J Psychiatry. 2002 Feb;159(2):297-301.
?These findings support the hypothesis that there is an association between Borrelia burgdorferi infection and psychiatric morbidity. In countries where this infection is endemic, a proportion of psychiatric inpatients may be suffering from neuropathogenic effects of Borrelia burgdorferi.?
Poland: Klinika Psychiatrii, Białymstoku.
Rudnik I, Konarzewska B, Zajkowska J, Juchnowicz D, Markowski T, Pancewicz SA.
Pol Merkur Lekarski. 2004 Apr;16(94):328-31.
?Mental state examinations and psychometric testing revealed in majority of the patients, mainly in those suffered from neuroborreliosis and erythrema migrans evidence of various psychiatric symptomatology. The range of psychiatric presentations included: mild cognitive deficits, organic mood disorders, mild dementias, depressive and anxiety episodes with non organic etiology.?