A 64 year old African-American man from Prince George County, Maryland died from severe and rapidly fatal interstitial lung disease after being treated with what was reported to be "appropriate antimicrobial therapy" for acute Lyme disease. It is believed he was exposed to ticks while mowing his lawn.
"This case illustrates that in patients who are diagnosed with lyme infection who subsequently develop atypical muscular, respiratory or other systemic complaints, the possibility of severe rheumatological and pulmonary complications should be considered."
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J Med Case Reports. 2010 Jun 21;4:187.
Acute lyme infection presenting with amyopathic dermatomyositis and rapidly fatal interstitial pulmonary fibrosis: a case report.
Nguyen H, Le C, Nguyen H.
Internal Medicine Department, Kaiser Permanente, Mid-Atlantic, 6104 Old Branch Avenue, Temple Hills, MD, 20748, USA. firstname.lastname@example.org.
INTRODUCTION: Dermatomyositis has been described in the setting of lyme infection in only nine previous case reports. Although lyme disease is known to induce typical clinical findings that are observed in various collagen vascular diseases, to our knowledge, we believe that our case is the first presentation of acute lyme disease associated with amyopathic dermatomyositis, which was then followed by severe and fatal interstitial pulmonary fibrosis only two months later.
CASE PRESENTATION: We present a case of a 64-year-old African-American man with multiple medical problems who was diagnosed with acute lyme infection after presenting with the pathognomonic rash and confirmatory serology. In spite of appropriate antimicrobial therapy for lyme infection, he developed unexpected amyopathic dermatomyositis and then interstitial lung disease.
CONCLUSIONS: This case illustrates a potential for lyme disease to produce clinical syndromes that may be indistinguishable from primary connective tissue diseases. An atypical and sequential presentation (dermatomyositis and interstitial lung disease) of a common disease (lyme infection) is discussed. This case illustrates that in patients who are diagnosed with lyme infection who subsequently develop atypical muscular, respiratory or other systemic complaints, the possibility of severe rheumatological and pulmonary complications should be considered.
PMID: 20565951 [PubMed - in process]PMCID: PMC2898701Free PMC Article