Babesioosi voi levitä mm verivalmisteiden välityksellä. Siitä huolimatta verivalmisteita ei tutkita niiden varalta, ei niissäkään maissa joissa babesioosia esiintyy yleisemmin kuten USA. BAbesioosi voi olla tappava erityisesti immuunipuutoksesta kärsivien kohdalla. FDAn tutkija Kumar sanoo olevansa erittäin huolestunut verivalmisteiden turvallisuudesta.
http://www.nytimes.com/2011/06/21/healt ... .html?_r=1
Once Rare, Infection by Tick Bites Spreads
By LAURIE TARKAN
Published: June 20, 2011
A potentially devastating infection caused by tick bites has gained a foothold
in the Lower Hudson Valley and in coastal areas of the Northeast, government
researchers have found.
Without a test for babesiosis, caused by a parasite carried in ticks, its spread
may threaten the blood supply.
The condition, called babesiosis, is a malaria-like illness that results from
infection with Babesia microti, a parasite that lives in red blood cells and is
carried by deer ticks. Though far less common than Lyme disease, babesiosis can be fatal, particularly in people with compromised immune systems.
Because there is no widely used screening test for babesiosis, its spread poses a particular threat to the blood supply, scientists said. "We are very worried about it and are doing everything in our power to address this," said Sanjai Kumar, chief of the laboratory of emerging pathogens at the Food and Drug Administration.
According to a recent report by the Centers for Disease Control and Prevention, there were six cases of babesiosis in the Lower Hudson Valley in 2001 and 119 cases in 2008, a 20-fold increase. In areas where Lyme disease is endemic, like coastal Rhode Island, Massachusetts, Connecticut and Long Island, babesiosis also is becoming very common, said Dr. Peter Krause, senior research scientist at the Yale School of Public Health.
In one study of residents of Block Island, R.I., Dr. Krause found babesiosis to
be just 25 percent less common than Lyme disease. Babesiosis also is spreading slowly into other regions where it did not exist before, like the Upper Midwest, said Dr. Krause.
Many people who are infected with the parasite have no symptoms at all, while
others experience mild to moderate flu-like symptoms that may last for a few
days or as long as six months. "But some people get so sick that they wind up
hospitalized, put into an intensive care unit, or even dying," said Dr. Gary
Wormser, chief of infectious diseases at Westchester Medical Center in New York.
In states that track the disease, there are an estimated 1,000 reported cases a
year, said Dr. Krause, but he and other experts believe this represents a
fraction of the people who are infected. In the Block Island study, researchers
tested about 70 percent of the islanders and found that about one quarter of
adults and half of children who were infected had no symptoms and were therefore not reported. Even people with mild to moderate symptoms may never see a physician. Even if they do, the condition may not be accurately diagnosed.
Experts fear that many undiagnosed patients may be donating blood. Currently,
blood banks do not screen for Babesia because the Food and Drug Administration has not licensed a test for this purpose. The only way to screen a patient is by using a questionnaire, which simply asks blood donors if they are infected.
Babesiosis already is the most frequently reported infection transmitted through
transfusion in the United States, responsible for at least 12 deaths. In New
York City, six transfusion-associated cases of babesiosis were reported in 2009.
Infection by this route can be serious: One study found approximately 30 percent of people who were infected by a transfusion died.
Between 1999 and 2007, several infants in Rhode Island developed babesiosis
following blood transfusions. The Rhode Island Blood Center has become the first in the country to use an experimental new test to screen blood for the parasite.
Experts urge blood transfusion patients and their doctors to be aware of
symptoms of babesiosis, which can occur up to nine weeks after a transfusion.
The symptoms can be vague (there is no tell-tale rash as there may be with Lyme disease) and include fever, sweats, chills, headache, fatigue, and muscle aches and pains. In people who also have Lyme disease, doctors might suspect babesiosis if the symptoms are particularly severe or the antibiotics are not working, said Dr. Krause. A diagnosis can be confirmed through blood testing.
Infants and adults over age 50 are more likely to get moderate to severe
symptoms if infected. People at increased risk of complications include patients with compromised immune systems (such as people receiving immunosuppressants), those who've had their spleens removed, and those with lymphoma or H.I.V. or who are being treated for cancer.
If not caught and treated early, babesiosis can lead to such complications as
kidney, lung or heart failure. The infection can be treated with antimicrobial
medications, but people with serious complications are less responsive to the
Why the parasite is spreading and why it's spreading more slowly than Lyme
disease are not well understood. One theory is that Babesia may be carried
primarily in mice, which don't tend to travel far afield. The bacterium causing
Lyme disease, Borrelia burgdorferi, can be carried by birds.