Tri James R.Shannon "Ainoa turvallinen rokote on sellainen jota ei ole otettu."
http://vactruth.com/2011/06/06/part-1-o ... jczak-phd/
An Interview About Vaccines with Helen V. Ratajczak, PhD
By Catherine J. Frompovich | June 6th, 2011 | Category: Catherine Frompovich, Interviews, Top Stories | 3 Comments and 11 Reactions
?The only safe vaccine is one that is never used.?
Dr. James R. Shannon, former Director, National Institute of Health [1955-68]
In today?s environment of mandatory vaccines with no safety studies performed on them by the U.S.FDA?at least according to Congressional Hearings on vaccines and autism held 1999-2004?since they would cost too much per FDA, health consumers are left in the dark as to why their children experience horrible health problems post-vaccination. That is not a rash statement. All one has to do is check out the thousands of vaccine adverse reaction reports filed with the CDC?s VAERS reporting system. See http://vaers.hhs.gov/index
. Until September 2, 2010, almost $2Billion in claims was paid for vaccine-related damages. Here?s where to file a vaccine adverse reaction http://vaers.hhs.gov/resources/vaers_form.pdf
Wanting to know more from a scientist?s point of view?especially one who worked in the field of immunology and toxicology, I thought that an interview with Helen V. Ratajczak, PhD, could shed some light on a few questions that I had. Dr. R was extremely gracious about the interview. She answered every question I put to her along with providing citations and documentation. She has more than 100 publications and presentations to her credit.
Since retirement, Helen V. Ratajczak, PhD, is focusing on research on Autism. Her most recent pre-retirement position was that of senior scientist at Boehringer Ingelheim Pharmaceuticals, Inc., where she performed safety testing on components of medicines. In addition, Dr. R measured biomarkers and other substances in the peripheral blood of different species of animals and conducted hypersensitivity tests.
Prior to that position, she worked at IIT Research Institute, and was the leader of the Immunology Group. Research there included designing and performing hypersensitivity testing, studying the chronobiology of immunologic endpoints in the mouse and directing the research of graduate students. Ratajczak also taught applied immunology to graduate students at IIT.
Former positions that Ratajczak occupied in her long career included working at medical schools where she studied a mouse model of breast cancer, immunology of the eye, and hypersensitivity pneumonitis in the rabbit model of farmers? lung disease. Her PhD research was on respiratory syncytial virus in a golden Syrian hamster model. The research for her MS degree was on rheumatoid arthritis in the human. Her BS degree was in chemistry with a mathematics and physics minor.
Throughout Ratajczak?s illustrious career she focused on immunology and toxicology with an emphasis on hypersensitivity.
With such impeccable credentials, Dr. Ratajczak is more than qualified to discuss immunological and hypersensitivity issues currently surrounding mandatory vaccinations for infants, toddlers, and teens in the United States.
During our interview I asked questions pointed at specifics that seem to have become ?untouchables? for the media?especially investigative journalists?that provide the foundation of Big Pharma?s vaccine ideology.
Globally, parents are prosecuted at law for harming their children when, in reality more often than realized, the damage to children is vaccine-related brain encephalopathy that medical personnel are quick to label as Shaken Baby Syndrome (SBS).
Q. 1. Shaken Baby Syndrome is now suspected as a vaccine adverse reaction when no real trauma is present on the body and/or head. How do vaccines cause intracranial swelling and /or bleeding?
Vaccines cause intracranial swelling and/or bleeding by their action as vaccines. In other words, a vaccine causes an immune response, which involves production of antibodies and sensitization of thymic-dependent lymphocytes that are specific for the antigen (bacterium or virus in the vaccine). In some cases there are cross-reactions of the antibodies specific for the vaccine antigen(s) with brain antigens. For example, measles IgG positive autistic sera were also positive for brain antigens: 90% were positive for anti-myelin basic protein and 73% for anti-neuron-axon filament protein. A cross-reaction was also present for human herpesvirus-6 antibody in autistic sera that was similarly positive for brain antigens. Eighty-four (84) % were positive for anti-myelin basic protein and 72% for anti-neuron-axon filament protein. (See Ratajczak, 2011; Singh et al., 1993, 1998, 2002.) In addition, in children with autism, neuron-specific antigens may cross-react with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. The antibodies may have been synthesized as a result of an alteration in the blood-brain barrier, allowing preexisting T-lymphocytes and central nervous system antigens access to immunocompetent cells, which may start a vicious cycle (Vojdani et al., 2002). The immune system would react against those targets for which specific reactions (antibody and cell-mediated immunity) were made, killing them.
When cells of the immune system are sensitized, the cells divide. Therefore, there is more cellular mass in the lymph nodes that drain the antigen presentation site. In addition, the cells make cytokines, which cause other cells to come into the area. Inflammation is a protective and restorative reaction of the body. However, when it is not controlled, and becomes chronic, there is continued presence of lymphocytes, polymorphonuclear leukocytes, monocytes, and plasma cells, antibodies and cytokines. Chronic inflammation may be caused by persistence of foreign material, such as a vaccine. The adjuvant in the vaccine causes its absorption by the body to be very long in duration so that adequate sensitization is achieved to provide protection against the antigen in the vaccine.
Q. 2. From 32 to 52 weeks of an infant?s life, there is accelerated brain growth with limited myelin protection. However, during that time infants receive about 21 vaccines. What impact is there upon infants? CNS, physical brain, and immune system?
In the USA, in 2010, 50 doses of 14 vaccines are given by the age of six years with Hip B given at birth, and again at 2 months along with Rotavirus, Diphtheria, Tetanus, Pertussis (three vaccines in one injection), Homophiles influenza type b, pneumococcal, and inactivated poliovirus (CDC, 2010). Two months is the most vulnerable age immunologically. Most infant mortality occurs at 2 months because the protection from the mother?s immunity is waning, and the child?s immunity is still immature. At two months, the polymorphonuclear cells are less in number than the lymphocytes in the peripheral blood, opposite the normal situation with the polymorphonuclear cells being about twice the number of lymphocytes (Diem, 1962). In addition, the phagocytic cells and complement system of a newborn are decreased in function (Xanthou et al., 1975; Madden et al, 1989). Thus, the immune system is compromised at two months. A challenge by so many vaccines while the immune system is compromised might contribute to an onset of autism (Ratajczak, 2011). The inflammation caused by the vaccines would damage the central nervous system and brain.
The inflammation persists, resulting in increased head circumference, noted at one month of life and peaking at 6 months with a smaller difference at 12 months, compared to neurotypical controls (Fukumoto, 2008). When the brain is growing so rapidly (between 32 and 52 weeks of age), the infants receive over 21 vaccines (Buttram, 2008).
Q. 3. What can happen if an infant suffered an earlier brain hemorrhage (possibly undetected during birth, i.e., during vacuum extraction or from forceps) and then receives vaccines, e.g., Hep B at birth, then at 2, 4, 6 month schedules. Is there any probability of vaccine-induced lipid peroxidation? If yes, what happens to an infant?s brain?
The hemorrhage would deplete the body of blood cells, and the regeneration of those cells would take more time than in an older host. The infant would be even more vulnerable after a hemorrhage, and the insult of vaccines at birth and at 2, 4, and 6 months could cause death. It is best not to give vaccines to an immune-compromised individual. Vaccines do cause lipid peroxidation, which, along with antibody specific for the antigens in the vaccines cross-reacting with elements of the brain, cause cell death.
Q. 4. What role, if any, do vaccines play in Sudden Infant Death Syndrome (SIDS)?
Epidemiology links vaccines with the Sudden Infant Death Syndrome. Cherry et al. (1988) suggested a link between the Japanese vaccination schedule and SIDS because after infant deaths occurred directly after vaccination between 1970 and 1974 in Japan, some doctors gave no vaccines to infants for two months, and then began vaccinations only to children 2 years old or older. Japan jumped from 17th place in child mortality to the lowest child mortality in the world (Vaccine Awareness Network, 05 May, 2011). Similar results happened in other countries, such as the United Kingdom. The postneonatal mortality dropped in 1976 when there was publicity about the whooping cough vaccine causing brain damage, and the vaccination rate fell to only 10 ? 30%, with a concomitant fall in infant mortality rate. Similar results were achieved in India.
Q. 5. Are you familiar with the Pourcyrous brain inflammation studies reported in the Journal of Pediatrics in 2007? If yes, any comments, please.
The Pourcyrous study (2007) was conducted to determine the incidence of cardiorespiratory events and abnormal C-reactive protein level associated with administration of a single vaccine or multiple separate vaccines simultaneously. The subjects were 239 preterm infants at >2 months of age in the neonatal intensive care unit. Each infant received either a single vaccine or multiple vaccines on one day. CRP levels and cardiorespiratory manifestations were monitored for 3 days following immunization. CRP levels were elevated in 85% of those given multiple vaccines and up to 70% of those given a single vaccine. Sixteen (16) percent had vaccine-associated cardiorespiratory events within 48 hours. Abnormal CRP values were associated with multiple vaccines and severe intraventricular hemorrhage. Cardiorespiratory events were associated marginally with receipt of multiple injections and significantly with gastroesophageal reflux. The study was the first of its kind, and presents a unified theory of adverse vaccine reactions (Buttram, 2010). The data provide evidence for a unified theory of adverse vaccine reactions: Brain inflammation, as indicated by elevations of CRP; brain swelling (edema), as one of the cardinal manifestations of inflammation; potentially lethal cardio-respiratory events (bradycardia and apnea); and intraventricular brain hemorrhages.
The brain hemorrhages in the study were intraventricular rather than subdural because the subjects were preterm infants, in whom intraventricular hemorrhages are characteristic. In preterm infants the skull is highly flaccid, providing little if any resistance to a swollen (edematous) brain. In contrast, in term infants, the inner surface of the skull is a relatively firm surface, and when brain inflammation and edema take place from vaccines, it requires very little brain swelling for the outer surface of the brain to impact against the inner surface of the skull, cutting off the passive outflow of blood in the subdural venous network. With cranial arterial blood coming in at much higher pressures, this would bring a precipitous rise in intracranial venous pressure, causing an extrusion of blood into the subdural spaces.
At this point I?d like to interject that Harold E. Buttram, MD, and I co-authored a comprehensive paper on brain encephalopathy using the Pourcyrous study as our ?jumping off point? for what we call, ?Vaccines and Brain Inflammation.? Our paper is being published in an online vaccine medical journal. I?d be interested in hearing your comments about it. To which Dr. Ratajczak replied, I am looking forward to reading it. Please give me a copy when it is available.
Q. 6. Formaldehyde is an EPA-declared carcinogen that is in many vaccines. Can you please talk about it and how it reacts in the body?
The Children?s Hospital of Philadelphia (2010) has addressed the issue of formaldehyde and concerns for safety. In cells grown in the laboratory, high concentrations of formaldehyde can damage DNA and cause cancerous changes. They state that formaldehyde does not appear to be a cause of cancer in man or in animals. Formaldehyde is essential in human metabolism and is required for the synthesis of DNA and amino acids. In all humans there are detectable quantities of natural formaldehyde. For a 2-month-old child, the total quantity of formaldehyde would be about 1.1 mg, at least five-fold greater than that to which an infant would be exposed by vaccines.
Q. 7. Polysorbate 80 causes infertility in lab rat studies, and it?s an ingredient in vaccines. What can you say about it?
Polysorbate 80 (also known as Alkest TW80, Tween 80, Polyoxyethylene (80) sorbitan monooleate, (x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl), POE (80) sorbitan monooleate, and E433) is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan and oleic acid, and is often used in foods. Polysorbate 80 is an excipient used to stabilize aqueous formulations of medications for parenteral administration and in some influenza vaccines, and the culture of Mycobacterium tuberculosis. (See Wikipedia, 2011a.)
It is important to remember what Paracelsus said centuries ago: ?What is there that is not poison? All things are poison and nothing [is] without poison. Solely the dose determines that a thing is not a poison.? (Eaton and Klassen, 1996.) With this is mind, the amount of any ingredient might be safe in a particular vaccine. However, when combined with other vaccines or when given repeatedly, other mechanisms can be brought into play. For example, vaccines typically contain adjuvants. Several vaccines containing adjuvants, either the same adjuvant or ones of different compositions, can add up to a toxic situation, either additively, or, worse, synergistically. [CJF emphasis added] In addition, the components of the adjuvants can themselves be antigenic, causing immune responses specific for their constituents.
Some toxic aspects of Polysorbate 80 follow: Polysorbate 80 has been identified as the causative agent for the anaphylactoid reaction of nonimmunologic origin in the human. Polysorbate specific IgE antibodies were not identified, confirming the nonimmunologic nature of the anaphylactoid reaction (Coors et al.,, 2005). In addition, delayed effects of neonatal exposure to Tween 80 on female reproductive organs in rats have been documented (Gajdova et al., 1993). Also in rats, a study in 1956 saw no effect of Polysorbate 80 on reproduction at up to 5% of their diet. But reproduction decreased at 20% of the diet. This study was performed when the rats were sexually mature (110 days old). (See Oser and Oser, 1956.) In contrast, a study on neonatal female rats injected with Polysorbate 80 on days 4-7 after birth showed that the Polysorbate 80 prolonged the estrus cycle, and induced persistent vaginal estrus. The relative weight of the uterus and ovaries was decreased relative to untreated controls. These two studies exemplify the critical windows of time during which individuals are more vulnerable (Dietert and Dietert, 2008; Ratajczak, 2011).
The data suggest Polysorbate 80 could cause reproductive problems in vaccine recipients. Therefore more safety tests are needed prior to use of products containing this product. [CJF emphasis added]
Q. 8. Many folks are turned off of vaccines because of aborted fetal cell mediums they are grown on. There?s speculation that diploid cells, as they are referred to, interact adversely within an infant?s brain, almost like turning against brain cells? What can you say about the diploid cell connection to Autism?
The theory about the harm caused by growth in human tissue of viruses to be used in vaccines is that human DNA will be in the resultant viruses. (When a virus grows, it must be inside a cell, and as the virus matures, it takes part of the cell ? in this case, DNA ? with it.) And that human DNA will be from a different individual that the recipient of the vaccine. When DNA from one human is introduced into another human, there is the possibility of homologous recombination (Wikipedia, 2011b), with the new DNA being incorporated into the recipient?s DNA. Now the recipient of the vaccine would have altered DNA (altered self) in his body. The immune system kills altered self or this altered DNA. This constitutes an autoimmune situation, which is ongoing throughout life. It is known that there are autoimmune components to autism. In recipients of vaccines containing human DNA, the autoimmunity could be caused by the DNA from the human tissue in which the virus was grown. Homologous recombination only occurs if the DNA is from the same species. So the use of viruses grown in tissue from other animals would not result in homologous recombination.
Q. 9. What do you have to say about foreign DNA from insects, monkeys, chicks, pigs, bovine calf, etc. in vaccines?
Foreign DNA from insects, chickens, or mammals other than humans would not be incorporated into the DNA of the recipient of the vaccine. However, there are sometimes other concerns about the use of these sources in which to grow the vaccine components.
Dr. Ratajczak, what are some of those other concerns? Can you please clue us in on that?
For example, viruses likely to be encountered in vaccine production using monkey kidney cells include B virus, miscellaneous simian viruses, ?foamy agent?, ?measles?-like agent, haemadsorption viruses, lymphocytic chorio-meningitis (LCM) virus and arbor viruses. The B virus, LCM, measles and the arbor viruses are definite human pathogens. (See Tobin, 1960).
There is a possibility that allergies to the tissue in which the vaccine components are grown will develop in recipients of the vaccines.
During her career, Dr. Ratajczak developed an ELISA assay for Rat Alpha-2-Macroglobulin, the most sensitive acute phase reactant protein for the rat, and also quantitated acute phase reactant proteins in the dog and monkey. She also conducted acute toxicology studies and both in vivo and in vitro immune assays, and has studied the immunotoxicologic properties of many compounds, including immunosuppressive and immunostimulatory drugs, in several animal species including mice, rats, nonhuman primates, and humans.
We continue on with my interview.
Q. 10. Will you please contrast a single dose vaccine versus multiple dose vaccines.
In the past, many vaccines were packaged in large vials so that multiple doses could be given from the same vial. These vials typically contained thimerosal to inhibit the growth of bacteria that might be introduced as a result of entering the vial multiple times. In contrast, a single dose vaccine is one that is packaged in a vial containing only one dose. Thus the vial is only entered a single time, and typically does not contain any anti-bacterial agents.
Q. 11. Can you talk about ?hidden? vaccine adjuvants that do not appear on package inserts, e.g., peanut oil in particular, and any impact that it may have had on so many children having peanut allergies now.
In the 1968 Hong Kong influenza pandemic, a new vaccine preparation was tested. In a publication in 1969, it is stated an influenza vaccine in adjuvant 65 (made with peanut oil) increased the antibody response to influenza virus even when the antigen was reduced 4-fold or more. In addition, the use of the adjuvant gives a considerable broadening of antibody response against diverse serotypes. At the time of publication, the authors state the vaccine in adjuvant 65 had been given to more than 16000 persons without untoward effect. In addition, no pyrogenic or other systemic reaction has been noted to follow vaccine in adjuvant 65, in contrast to the reaction which sometimes follows aqueous vaccine (Hilleman, 1969). Other investigators confirm the advantages of the use of adjuvant 65 in the influenza vaccine, with an increase in antibody titer and a broader response to both Influenza A and B antigens. Subjective reactions each of 5 days following vaccination showed more pain was recorded by recipients of the oil adjuvant compared with those given an aqueous preparation, but local redness was more frequent after the aqueous vaccine, and systemic symptoms were recorded a little more often after aqueous than oil adjuvant vaccine (Smith et al., 1975). However, no mention was made of looking for reactions to other components of the vaccine, such as the peanut antigen. When a vaccine is given, an immune response follows. This response can be specific for any of the components of the vaccine, including the source of oil in the adjuvant. In this case, that would be the peanut. Therefore, a vaccine containing peanut oil could cause allergy to the peanut. The ?inactive? components of the vaccine need not be listed on the ingredients list (Gregory, 2009). [CJF emphasis]
Q. 12. Please talk about how adjuvants are designed to over-stimulate immune response that, in turn, can attack brain microglia and astrocytes. What happens? Do adjuvants interfere with nerve pathway development? Do they incite glutamate and quinolenic acid? What are the resultant consequences?
The adjuvant and the antigen are two separate components of a vaccine. The antigen is the component that the vaccine is designed to protect against, such as influenza. The adjuvant is the added component that causes an enhancement of the immune response by slowing the release of the antigen into the body. The immune system responds to the presence of antigen and terminates the response once the antigen is eliminated. When the antigen is mixed with an insoluble adjuvant, a focus is formed, and the antigen within the focus slowly leaks into the body, giving a prolonged antigenic stimulus. (Tizard, 1988).
In the case of the immune system?s attack on brain microglia and astrocytes, there is a cross reaction of the antibody against the antigen and the brain cells. (The configuration of the brain cells or parts of them is similar to the antigen.) Therefore, the immune system attacks the brain cells. [Refer to HVR?s answer to question 1 in Part 1.]
The adjuvant, as stated above, causes the antigen to be released to the body very slowly, thus augmenting the immune response. Indirectly, the adjuvant could be responsible for the interference with the development of nerve pathways, but the direct reason is the cross-reaction of specificity of the immune system.
Besides eliciting an immune response that is specifically against the antigen, the vaccine elicits a number of cytokines or factors, which enhance or regulate the immune response. The cytokines caused by the vaccine cause the secretion of harmful chemicals including two excitotoxins, glutamate and quinolenic acid (Blaylock, 2008). These chemicals elicit an excitatory reaction in the neurons, and create cellular toxicity and inflammation if too much accumulates (Jepson, 2007; Reynolds, 2007).
Q. 13. Please talk about aluminum adjuvants, which come in four formulations. Is any one more harmful than the others? Aluminum hydroxide, aluminum hydroxyphosphate sulfate, aluminum phosphate, aluminum potassium sulfate.
The aluminum adjuvants are effective in increasing the immunogenicity of vaccines. The four adjuvants listed are currently used in childhood vaccines such as DTaP, Hep A, Hep B, HiB, human papillomavirus (HPV), DTaP, DTAP-HepB-IPV, Pneumococcal DT, Td, etc. These four adjuvants have different isoelectric points and properties, and they are not interchangeable. The efficacy of each salt as an adjuvant depends also on the characteristics of the antigens in the vaccine. Adverse reactions include sterile abscesses, erythema, subcutaneous nodules, granulomatous inflammation and contact hypersensitivity (Eickoff and Myers, 2002.) I have not found data on the relative toxicity of these four aluminum adjuvants. However, in the workshop summary on aluminum in vaccines, Eickhoff and Myers report that Aventis Pasteur, France has planned studies and is already working on examination of the evolution of aluminum adjuvant-associated histology. In addition, in vitro studies of human macrophages exposed to various aluminum salts are planned.
Aluminum-containing vaccines have more than a 75-year record of safety around the world, with serious adverse effects being rare. (National Network for Immunization Information, 2008). Despite this, many manifestations of the toxicity of aluminum are documented.
Aluminum is established as a neurotoxin, although the basis for its toxicity is unknown. Aluminum alters the function of the blood-brain barrier, which regulates exchanges between the central nervous system and peripheral circulation. Aluminum increases the rate of transmembrane diffusion and selectively changes saturable transport systems without disrupting the integrity of the membranes or altering central nervous system hemodynamics. Such alterations in the access to the brain of nutrients, hormones, toxins, and drugs could be the basis of central nervous system dysfunction. (See Banks and Kastin, 1989).
Aluminum in vaccines has a potential to induce serious immunological disorders in humans, particularly autoimmunity, long-term brain inflammation and associated neurological complications. (See Tomljenovic and Shaw, 2011).
Macrophagic myofascitis is a term used to describe microscopic findings in some muscle biopsies. The lesions are thought to be caused by tissue changes resulting from the normal immune response to the aluminum-absorbed vaccine (Verdier, 2005). In France, biopsy findings are described in adult patients who had muscle and joint aches and pains and fatigue. The physician who first described the biopsy findings proposed that aluminum-containing vaccines caused the symptoms (Gherardi, 1998).
In another report, aluminum hydroxide injections are tied to motor deficits and motor neuron degeneration (Shaw and Petrick, 2009).
Q. 14. Can you please discuss the interaction of mercury as found in Thimerosal (49.6% Hg) and aluminum together in a vaccine.
The addition of Thimerosal to a vaccine in an adjuvant containing aluminum can result in a synergistic toxicity. (See Haley, 2005). Haley reports that aluminum hydroxide alone showed no significant death of neuron cells in culture at six hours, and only slight toxicity over 24 hours. Similarly, Thimerosal caused only a slight increase in neuron death at 6 hours. When Thimerosal and aluminum hydroxide were added together, neuronal death increased to 60%. This is an example of a synergistic effect of two toxicants. [CJF emphasis]
Dr. Ratajczak was or remains a member of Sigma Xi; American Thoracic Society; American Association of Immunologists; International Society of Chronobiology; Society of Toxicology Immunotoxicology Subspecialty Section; North East Chapter of Society of Toxicology and the Autism Society of America.
Now, to the last of my interview questions.
Q. 15. Why do vaccines increase blood histamine levels?
Vaccines activate the immune system that responds in a specific way to the antigen in the vaccine, but, in the process, the vaccines also cause inflammation, which is a defense mechanism in which there is increased vascular permeability and release of mediators. Mast cells and basophils have receptors for both C3a and C5a, components of the complement cascade, which is intimately involved in inflammation. Reaction of the complement components with their receptors can cause degranulation of the mast cells and basophils, with the release of histamine and other mediators of anaphylaxis and inflammation. (See Golub and Green, 1991a.)
Q. 16. Do vaccines decrease Vitamin C levels? If so, what does that imply?
Yes, vaccines do decrease Vitamin C (ascorbic acid) levels. The adjuvants in vaccines are pro-oxidants that drain the body?s supply of antioxidants including vitamin C (Buttram, 2010). Any infection, even the common cold, causes a sharp drop in the blood leukocyte Vitamin C concentration (Clemetson, 1999; MacLennan, 1977). Vitamin C acts as a coenzyme or cofactor, and promotes resistance to infection through the immunologic activity of leukocytes, production of interferon, process of inflammatory reactions and the integrity of the mucous membranes (Mahan, 1992). The drop in Vitamin C levels implies that the Vitamin C was used in response to the infection or vaccine. Vitamin C deficiency is correlated with a highly significant increase in blood histamine level, which would promote allergic reactions. (See Q15) The Vitamin C promotes the detoxification of histamine by converting it to hydantoin-5-acetic acid and then to aspartic acid. When blood Vitamin C levels fall below 1 mg/100ml, the whole blood histamine level increases exponentially as the ascorbic acid level decreases. Oral administration of ascorbic acid decreases the blood histamine levels (Clemetson, 1980).
Q. 17. Can peroxidation occur in the brain from vaccine adjuvants?
Yes, peroxidation can occur in the brain from vaccine adjuvants. The brain has the highest fat content of any organ of the body with membrane lipids being 60% of the solid matter (Buttram, 2010; Sing, 2005). The adjuvants are pro-oxidants that drain the body?s supply of antioxidants including Vitamin C.
Q. 18. Please talk about lipid peroxidation and brain swelling/inflammation. Is there any impact on myelin development or demylination?
Lipid peroxidation occurs when vaccine adjuvants interact with lipids in the brain. See answer to Question 17 above. The inflammation that results in brain swelling also causes demylination.
Q. 19. Elevated C-Reactive Protein (CRP) blood test results indicate elevated inflammation in the body. Should that be a standard test in assessing Shaken Baby Syndrome or Autism Disorder Spectrum (ADS)?
C-Reactive Protein (named because it binds to the C protein of pneumococci) is an acute phase reactant protein, one that is at low levels in normal serum. Its level increases rapidly to 100X those in normal serum within hours after infection, inflammation, or tissue damage. C-reactive protein binds to the surfaces of a variety of bacteria and fungi and activates complement and increases phagocytosis. (See Golub and Green, 1991b.) Quantitation of CRP could be part of a test to indicate inflammation as a result of Shaken Baby Syndrome or Autism Disorder Spectrum.
Q. 20. Some researchers claim that 2 toxins (e.g., Hg & Al) in a single vaccine increase toxicity ten-fold and that 3 toxins (e.g., Hg, Al, Formaldehyde) in a single vaccine increase toxicity a hundred-fold. What is your comment about that?
The increase beyond additivity in toxicity when 2 or more toxins interact is called synergism. This is a very serious consideration, and safety tests must consider this possibility. [CJF emphasis]
Q. 21. Can vaccines cause ?cytokine storms? (hypercytokinemia) in infants? Can you talk about that at length a little, as parents?and maybe some MDs and emergency room docs and nurses?aren?t aware of that type of adverse reaction to vaccines?
Yes, vaccines can and do cause hypercytokinemia, also known as cytokine storms (Ponce, 2008; Binstock, 2009). A cytokine storm results when the body?s immune system rages out of control, resulting in overwhelming inflammation, rapid organ failure, and death if not quickly diagnosed and treated (Children?s Hospital of Philadelphia, 2011). Immunostimulation may develop via modulation of pathways involved in immune system regulation. Binstock gives some side effects of various vaccines, taken from the CDC?s list of possible side effects from vaccines, which are given for individual vaccines. For DTaP: fever, swelling (for 1 to 7 days) of the entire limb in which the shot was given after the 4th or 5th dose of DTaP vaccine; fussiness; tiredness or poor appetite; vomiting; jerking or staring; non-stop crying for 3 or more hours; fever of >105 degrees Fahrenheit; long-term seizures, coma or lowered consciousness; permanent brain damage. For Hib: fever > 101 degrees Fahrenheit. For MMR: fever, seizure; temporary low platelet count (which can cause a bleeding disorder); temporary pain and stiffness in the joints, mostly in teenage or adult women; long-term seizures, coma, or lowered consciousness, permanent brain damage. For Vermicelli: Fever, mild rash, up to a month after vaccination. Binstock notes that the first dose of MMRV vaccine has been associated with rash and higher rates of fever than MMR and varicella vaccines given separately. Seizures caused by a fever are also reported more often after MMRV. In addition, usually occurring 5-12 days after the first dose, vaccines can induce seizure (jerking or staring), caused by fever and other serious problems (which are very rare) including severe brain reactions and low blood count.
Two manuscripts that describe means of ameliorating cytokine storms follow: The Children?s Hospital of Philadelphia (2011) conducted a study on clues to calming a cytokine storm. Included in those suffering from cytokine storm, children with juvenile arthritis and patients with lupus or Epstein-Barr virus infection may also suffer from macrophage activation syndrome (MAS). The study reports development of an animal model of MAS in mice, and differentiates MAS from hemophagocytic lymphohistiocytosis (HLH), which also causes a life-threatening cytokine storm in children. HLH is caused by a genetic mutation, but MAS is not. Inflammation from rheumatological diseases like systemic juvenile arthritis causes MAS by acting through immunological pathways. Two important molecules in the immune system control the severity of MAS: Interferon-gamma, which makes MAS more severe, and Interleukin-10, which has a protective effect.
Another study by Boukhvalova et al. (2006) describes a TLR4 agonist, monophosphoryl lipid A, which attenuates the cytokine storm associated with respiratory syncytial virus vaccine-enhanced disease.
Dr. Ratajczak, can you briefly explain respiratory syncytial virus vaccine-enhanced disease. That is something I?m not familiar with.
When vaccines were first made to prevent disease caused by the RNA viruses measles and respiratory syncytial virus, the vaccines were made against killed viruses, and injected with an aluminum-containing adjuvant intramuscularly. The vaccines did not confer protection, but introduced hypersensitivity to the vaccines. Some of the recipients, when they next encountered the vaccine in its natural state, were severely affected and died. After this, the vaccines were made with attenuated viruses, those treated so they would not divide at normal human body temperatures. (See Fulginiti et al., 1967, 1969; Kim et al., 1969, 1971).
I asked Dr. R if I were a dinwitty because I was not familiar with respiratory syncytial virus vaccine-advanced diseases, and she candidly replied, These events received a lot of attention at the time they happened, but once vaccines were produced with the attenuated viruses, the adverse reactions to the inactivated or killed virus vaccines were downplayed.
Lastly, what are your personal thoughts about vaccines and their implications in Autism and other childhood diseases or syndromes?
Vaccines have saved a great many lives throughout the years since they were first developed in the Middle East centuries ago, with the intradermal application of powdered smallpox scabs (variolation) for the prevention of smallpox. However, it is important to remember the wisdom of the Hippocratic oath to ?First, do no harm?. Epidemiologic data suggest that vaccines are intimately involved with autism. As more vaccines were given to children, and given at earlier ages, the incidence and prevalence of autism increased. [CJF emphasis]
There are many aspects of vaccines that cause autism. Some examples follow: The pertussis component of the DPT vaccine integrates into the G proteins, which are regulatory proteins, inhibiting their function (Megson, 2000). The metal aluminum in the adjuvant(s) accompanying the vaccine(s) is toxic (Shaw and Petrick 2009). In addition, the mercury in the preservative thimerosal is a known nerve toxin. This preservative was removed from most childhood vaccines around the year 2000 (Schechter and Grether, 2008), but still is present in some vaccines, the most pertinent being influenza, which is sometimes given to pregnant women. The fetus is thus exposed to mercury, a nerve toxin, when the brain is in its most formative stages.
About the time thimerosal was removed from most childhood vaccines, the host for the growth of some viral components of vaccines was changed from animal to human tissue. When a virus grows it takes some of the DNA of the host cells with it. This means that the vaccine using the virus now contains human DNA, which can be incorporated into the vaccine recipient?s DNA by homologous recombination. Now the vaccine recipient has altered DNA or altered self, which is attacked and killed by the immune system. Much of this killing occurs in the brain.
The federal government and Dr. Gerberding, Director of Vaccines at Merck & Co., Inc. say that autistic conditions can result from encephalopathy following vaccination (Child Health Safety, 2010).
It would be very beneficial if tests of the safety of vaccines were conducted on the following:
* Increasing the age at which the vaccines are given
(Many vaccines are given at 2 months of age, which is the most vulnerable age. At that age, the immune protection given by the mother is on the wane and the infant?s immune system is not yet competent.)
* The effects of injecting more than one vaccine at the same time, with perhaps toxic levels of the metals in adjuvants
* Preparation of a thimerosal-free influenza vaccine
* Cessation of the practice of giving vaccines to children who are ill or are immunologically incompetent
* Design of safer vaccines (without preservatives and without human DNA)
* Conduction of safety tests on animal models prior to clinical safety tests
Dr. Ratajczak, your six recommendations listed above to increase vaccine safety represent state-of-the art medical, vaccine, and pharmacological science to my way of thinking. If you, an immunology and toxicology research scientist, understand the need and recommend them, I have to wonder why those who are the driving force behind vaccines in the U.S. and elsewhere have not implemented such basic safeguards to human health, particularly for infants and toddlers?the future of humankind.
As a result of our interaction during this interview, I?ve concluded that your new post-retirement career focus on Autism certainly will contribute much to unraveling the cause of the Autism Spectrum Disorder (ASD). Unfortunately, we already know the effects.
Thank you for what you do to bring responsible research into the often-hyped world of vaccines and vaccinations