LISÄINFEKTIOIDEN TARTTUMINEN

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Neljältä perheenjäseneltä löydettiin bartonellabakteeria. Historialliset ja mikrobiologiset tutkimukset tukevat taudin tarttuneen lapsiin syntymän aikana tai heti sen jälkeen.


J Clin Microbiol. 2010 Apr 14. [Epub ahead of print]
Molecular evidence of perinatal transmission of Bartonella vinsonii subsp. berkhoffii and B. henselae to a child.

Breitschwerdt EB, Maggi RG, Farmer P, Mascarelli PE.

Intracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC (E.B. Breitschwerdt, R.G. Maggi, P. E. Mascarelli), and the Department of Pathology, North Shore University Hospital, 300 Community Drive, Manhasset, New York (P. Farmer).
Abstract

Bartonella vinsonii subsp. berkhoffii, Bartonella henselae or DNA of both organisms was amplified and sequenced from blood, enrichment blood cultures or autopsy tissues from four family members. Historical and microbiological results support perinatal transmission of Bartonella species in this family.


PMID: 20392912

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Isällä ja tyttärellä on bartonellan aiheuttamia neurologisia oireita.

Bartonella voi aiheuttaa sydän- ja niveltulehduksia, neurologisia oireita uupumusta jne. Bakteerin häätö elimistöstä voi olla vaikeaa. Yhä lisääntyvässä määrin erilaisten vertaimevien hyönteisten kuten kärpästen, kirppujen, täiden jne. on todettu levittävän bakteeria.

http://www.parasitesandvectors.com/content/3/1/29

Bartonella vinsonii subsp. berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease

Edward B Breitschwerdt email, Ricardo G Maggi email, Paul M Lantos email, Christopher W Woods email, Barbara C Hegarty email and Julie M Bradley email

Parasites & Vectors 2010, 3:29doi:10.1186/1756-3305-3-29
Published: 8 April 2010
Abstract (provisional)

Background

Bartonella vinsonii subsp. berkhoffii is an important, emerging, intravascular bacterial pathogen that has been recently isolated from immunocompetent patients with endocarditis, arthritis, neurological disease and vasoproliferative neoplasia. Vector transmission is suspected among dogs and wild canines, which are the primary reservoir hosts. This investigation was initiated to determine if pets and family members were infected with one or more Bartonella species.

Methods

PCR and enrichment blood culture in Bartonella alpha Proteobacteria growth medium (BAPGM) was used to determine infection status. Antibody titers to B. vinsonii subsp. berkhoffii genotypes I-III and B. henselae were determined using a previously described indirect fluorescent antibody test. Two patients were tested sequentially for over a year to assess the response to antibiotic treatment.
Results

Intravascular infection with B. vinsonii subsp. berkhoffii genotype II and Bartonella henselae (Houston 1 strain) were confirmed in a veterinarian and his daughter by enrichment blood culture, followed by PCR and DNA sequencing. Symptoms included progressive weight loss, muscle weakness, lack of coordination (the father) and headaches, muscle pain and insomnia (the daughter). B. vinsonii subsp. berkhoffii genotype II was also sequenced from a cerebrospinal fluid BAPGM enrichment culture and from a periodontal swab sample. After repeated courses of antibiotics, post-treatment blood cultures were negative, there was a decremental decrease in antibody titers to non-detectable levels and symptoms resolved in both patients.

Conclusions

B. vinsonii subsp. berkhoffii and B. henselae are zoonotic pathogens that can be isolated from the blood of immunocompetent family members with arthralgias, fatigue and neurological symptoms. Therapeutic elimination of Bartonella spp. infections can be challenging, and follow-up testing is recommended. An increasing number of arthropod vectors, including biting flies, fleas, keds, lice, sandflies and ticks have been confirmed or are suspected as the primary mode of transmission of Bartonella species among animal populations and may also pose a risk to human beings.

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Verensiirroista riski saada babesia-tartunta (2010)

Clin Lab Med. 2010 Jun;30(2):499-509. Epub 2010 May 6.
Emerging pathogens in transfusion medicine.

Dodd RY.

American Red Cross, Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD
20855, USA. dodd@usa.redcross.org

Although the risk of infection with hepatitis and human immunodeficiency viruses
from blood transfusions has been reduced to negligible levels, emerging
infections continue to offer threats. Such threats occur with any infection that
has an asymptomatic, blood-borne phase. In the past, it was thought that any
emerging transfusion-transmitted disease would have epidemiologic properties
similar to those of AIDS or viral hepatitis. Over the past 20 years, however,
greatest concern has arisen from variant Creutzfeldt-Jakob disease, West Nile
virus, and Babesia. These and other emerging infections are discussed in the
context of blood safety. Copyright (c) 2010 Elsevier Inc. All rights reserved.

http://eutils.ncbi.nlm.nih.gov/entrez/e ... md=prlinks
PMID: 20513567 [PubMed - in process]

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Bartonellan aiheuttama infektio on yleinen erityisesti lapsilla. Bakteeritartunnan voi saada eläinten pureman ja raapiman lisäksi esim. punkeista ja kirpuista. (2010)

Bartonella henselae and the Potential for Arthropod Vector-Borne Transmission
To cite this article:

Mark E. Mosbacher, Stephen Klotz, John Klotz, Jacob L. Pinnas. Vector-Borne and Zoonotic Diseases.
doi:10.1089/vbz.2010.0106.
Online Ahead of Print: October 25, 2010
Full Text: ? HTML ? PDF for printing (167 KB) ? PDF w/ links (167.8 KB)


Mark E. Mosbacher,1
Stephen Klotz,2
John Klotz,3 and
Jacob L. Pinnas2
1Third World Veterinary, Fountain Hills, Arizona.
2Department of Medicine, University of Arizona, Tucson, Arizona.
3Department of Entomology, University of California, Riverside, California.
Address correspondence to:
Mark Mosbacher
Third World Veterinary
PO Box 19558
Fountain Hills, AZ 85269
E-mail: markmosbacher@hotmail.com

Abstract

Introduction: Bartonella henselae, the causative agent of the illness referred to as cat scratch disease, is a common infection, particularly in children, and clinicians need to be aware of its potential transmission to humans by arthropod vectors such as fleas and ticks in addition to animal bites and scratches. The absence of a vertebrate bite or scratch does not preclude infection with B. henselae.

Materials and Methods: Literature regarding arthropod transmission of B. henselae was reviewed.

Results: B. henselae appears to be transmitted among cats and dogs in vivo exclusively by arthropod vectors (excepting perinatal transmission), not by biting and scratching. In the absence of these vectors disease does not spread. On the other hand, disease can be spread to humans by bites and scratches, and it is highly likely that it is spread as well by arthropod vectors.

Discussion: Clinicians should be aware that a common illness, infection with B. henselae, can be transmitted by arthropod vectors and a history of an animal scratch or bite is not necessary for disease transmission.